He worked in various parts of South India before opening a full time regular medical mission at Nazareth. He was soon called off for a higher commitment as the Bishop of Rangoon. The work he started, was handed over to Canon Arthur Margoschis in 1876, who was a visionary in the true sense. He is popularly known as the Father of Nazareth. He Christened the hospital with its present name on the St. Luke's Day i.e., 18th Oct. 1892. After his death in 1908, the hospital flourished in the able hands of Dr. Devaprium, Dr. Mrs. Western (1909 - 1912) and Rev. Dr. Welsh (1914 - 1916).

Dr. Rathnam Vedabodakam, a dedicated young doctor, took charge of the hospital as medical officer in 1916. He was ably assisted by his wife, Dr. Ruby Grace Vedabodakam. He played a major role in the growth of the hospital. Both infrastructural and medical services saw an exponential growth

He enjoyed great support from the community and well wishers. His motto of " To heal the sick and preach the Gospel " is still followed. After his retirement in 1958, a lot of doctors contributed to the well being of the hospital, with a special mention of Dr. Kamali Jeyaseelan who served from 1972 to 2002, under whom the hospital became 100 bedded.